Last update
3/25/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin C (as Ester-C® calcium ascorbate)
500 mg
556%
Citrus Bioflavonoid Complex
25 mg
**
Acerola Extract (Malpighia glabra) (fruit)
10 mg
**
Rose Hips (fruit)
10 mg
**
Rutin
5 mg
**
Top Medical Research Studies
5
We explored the effects of vitamin C on leg cramps in a group of 60 pregnant women through a double-blind trial. Participants received either calcium or vitamin C (1 g twice daily) as treatment. Our observations revealed that there was no significant difference in clinical improvement between the two treatment groups.
Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.
Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.
Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.
Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.
Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.
Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.
Read More
Most Useful Reviews
9
Invigoration noticed
1 people found this helpful
Reacta C has truly invigorated me and alleviated my leg fatigue.
Read More
9
Pain vanished
After five days of taking Ester-C Plus, my hereditary venous pain disappeared completely! Previously, I struggled with severe pain and had to bandage my legs. A friend recommended this vitamin C, and it has been a lifesaver! While I know my venous issues are still there and surgery may be needed in the future, I feel much better now. Unlike my previous medication, this did not cause stomach pains, and I am thrilled with its effects.
Read More
7.5
No sickness experienced
I’ve been using an excellent Vitamin C with Rutin from Solgar, initially for my varicose veins. The pain in my legs subsided, and I didn’t experience any “twisting” at night. My overall health improved, and remarkably, I didn’t fall ill throughout winter! As someone recovering from cancer, this was astonishing as I would usually take multiple sick leaves due to infections. My family also began taking Ester-C 500mg, and none fell ill during winter and spring. There were no side effects, only benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
- All Researches
5
We explored the effects of vitamin C on leg cramps in a group of 60 pregnant women through a double-blind trial. Participants received either calcium or vitamin C (1 g twice daily) as treatment. Our observations revealed that there was no significant difference in clinical improvement between the two treatment groups.
Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.
Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.
Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.
Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.
Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.
Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Invigoration noticed
1 people found this helpful
Reacta C has truly invigorated me and alleviated my leg fatigue.
Read More
9
Pain vanished
After five days of taking Ester-C Plus, my hereditary venous pain disappeared completely! Previously, I struggled with severe pain and had to bandage my legs. A friend recommended this vitamin C, and it has been a lifesaver! While I know my venous issues are still there and surgery may be needed in the future, I feel much better now. Unlike my previous medication, this did not cause stomach pains, and I am thrilled with its effects.
Read More
7.5
No sickness experienced
I’ve been using an excellent Vitamin C with Rutin from Solgar, initially for my varicose veins. The pain in my legs subsided, and I didn’t experience any “twisting” at night. My overall health improved, and remarkably, I didn’t fall ill throughout winter! As someone recovering from cancer, this was astonishing as I would usually take multiple sick leaves due to infections. My family also began taking Ester-C 500mg, and none fell ill during winter and spring. There were no side effects, only benefits.
Read More
7.5
Pain relief reported
I ordered it specifically for my mother. She takes it with biotin for leg pain, and she claims it has improved her condition.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Hammar M, Berg G, Solheim F, Larsson L. Calcium and magnesium status in pregnant women. A comparison between treatment with calcium and vitamin C in pregnant women with leg cramps. Int J Vitam Nutr Res. 1987;57:179. PubMed
Data last updated:
